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2024年3月12日发(作者：)

专利内容由知识产权出版社提供

专利名称：Systems and methods for massively parallel

combinatorial analysis of single cells

发明人：David Scott Johnson,Adam Shultz

Adler,Matthew James Spindler,Rena Aviva

Mizrahi

申请号：US16443381

申请日：20190617

公开号：US11111490B2

公开日：20210907

专利附图：

摘要：Provided herein are methods that enable parallel evaluation of multiple

functional nucleic acids in individual cells or subpopulations of cells, in the context of

incubation with other types of single cells. The key insight is concurrent measurement of

polynucleic acids derived from small populations of at least two different cell types, such

that function in one cell type is linked to the clonal identity of another cell. These

methods simultaneously process thousands, millions, or more single cells or small

populations of cells. The method integrates molecular, algorithmic, and engineering

approaches. This invention has broad and useful application in a number of biological and

medical fields, including immunology and drug discovery.

申请人：GigaGen, Inc.

地址：South San Francisco CA US

国籍：US

代理机构：Fenwick & West LLP

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